Merck Academy

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Applying Principles of Pharmacology to Clinical Practice

Adherence to Prescription Medications

Applying Evidence-Based Medicine to Clinical Practice

Applying Principles of Pharmacology to Clinical Practice

Bringing Medications From Bench to Bedside

Building Trust to Achieve Vaccine Confidence

Health Equity

Importance of Patient Diversity in Clinical Trials

Patient Engagement in Clinical Trials

Principles of Biomarkers in Drug Development and Diagnostic Clinical Support

Vaccinology the Science of Vaccines

Understanding Comparative Effectiveness Research

Learning Objectives

Provide an overview of the basic principles of pharmacology as they apply to clinical medicine.
Identify drug-related factors and patient characteristics that alter pharmacokinetics (PK) and pharmacodynamics (PD) of drugs.
Understand how PK and PD affect efficacy and safety of drug therapies.

Summary

Using knowledge of the principles of pharmacology in everyday practice may help clinicians maximize the efficacy and safety of drug therapies. This presentation provides an overview of principles of PK and PD, and explores how the effects of drugs are influenced by drug-associated factors and patient characteristics. The presenter reviews 4 key criteria that influence drug levels and kinetics in the body; specifically absorption, distribution, metabolism, and excretion. A deeper understanding of these concepts may help clinicians prescribe an appropriate therapeutic treatment regimen and reduce the possibility of adverse effects. Examples of drug-related factors and patient characteristics that impact PK and PD are emphasized.

About

Merck Academy presentations are live, in-person lectures, facilitated by Merck subject-matter experts. Merck Academy faculty have postdoctoral training and are engaged in a variety of medical and scientific activities.

These live presentations comprise a variety of general scientific topics, including drug discovery, vaccine development, outcomes research, clinical trials, and statistics. Additional topics continue to be developed and added.

Potential audiences for Merck Academy might include faculty, fellows, residents, and medical students. Merck Academy is not intended to provide continuing medical education (CME) credits.